Common use

Prandin contains active component Repaglinide which is used to stimulate insulin secretion from the pancreas in treatment of type 2 of diabetes mellitus together with a diet therapy and physical activities including combined treatment with metformin.



Dosage and direction

The medication is taken orally 15-30 minutes before a meal usually 3 times a day. Dosage is administered individually. Initial recommended dose is 0.5 mg. The dose may be increased only after 1-2 weeks of treatment if blood glucose levels require it. The maximum single dose is 4 mg, maximal daily dose is 16 mg. If the patient has taken other oral diabetes drug the recommended initial dose is 1 mg.



Precautions

Inform your doctor or pharmacist if you have liver impairments, kidney failure or disorders. The medication should be used with cautiousness in weakened patients and in patients before future major surgery.



Contraindications

Hypersensitivity, diabetes mellitus type 1, diabetic ketoacidosis with or without coma, severe liver dysfunction and/or kidney disease, pregnancy, breast-feeding. Prandin cannot be used in children and patients older than 75 y.o.



Side effects

Hypoglycemia,visual acuity loss, dyspepsia, transient increase in liver enzymes, allergic reactions.



Drug interaction

Beta-blockers, chloramphenicol, indirect anticoagulants (coumarin derivatives), NSAIDs, probenecid, salicylates, MAO inhibitors, sulfonamides, alcohol, anabolic steroids increase, calcium channel blockers, corticosteroids, diuretics (especially thiazide), isoniazid, niacin, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thyroid hormones weaken the effects of Prandin. Erythromycin, ketoconazole and miconazole slow down metabolism of Prandin while barbiturates, carbamazepine and rifampin stimulate it.



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

Symptoms of overdose include: hypoglycemia (hunger, fatigue and weakness, headache, irritability, anxiety, drowsiness, restless sleep, nightmares, behavioral changes (similar to ones observed during alcohol intoxication), poor concentration, slurred speech, vision problems, confusion, pallor, nausea, palpitations, cramps, cold sweats, coma, etc.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.